Two types of bone are found in the body—cortical and trabecular. (2020) 78:17–25. analyzed 147 SLE patients and observed that TBS had a higher diagnostic accuracy for vertebral fractures than densitometric measurements (area in the ROC curve for TBS, L spine and left femur BMD: 0.811 vs. 0.737 and 0.605, respectively), supporting the assessment of bone microarchitecture by TBS as an enhancer of the information provided by BMD and showing that TBS identified degraded microarchitecture mainly associated with vertebral fractures in SLE patients (34). The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. compared RA, SSc, and HS using TBS and DXA in conjunction (2, 5). Several studies confirmed that TBS can discriminate patients with altered bone microstructure and have proposed its use as a clinical-radiological tool in OP diagnosis in patients with chronic inflammatory rheumatic diseases, such as systemic sclerosis (SSc), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and ankylosing spondylitis (AS) (12–18). Best Pract Res Clin Rheumatol. The association between systemic bone loss and periodontitis remains unresolved; and the trabecular bone score (TBS) is a new index for assessing decreased bone quality. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. There is increasing evidence that TBS values are associated with the incidence of fractures in rheumatic diseases. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. They also stated that TBS is not influenced by spinal osteo-proliferation in AS patients, even in those with advanced spinal changes (49, 51). SLE causes significant trabecular bone loss, which is not due to corticosteroid therapy. Evaluation of bone quality by trabecular bone score (TBS) in systemic lupus erythematosus patients. 2020 Jul 25;21(1):299. doi: 10.1186/s12882-020-01944-0. doi: 10.1038/ncpendmet0372, 56. (2019) 20:5867. doi: 10.3390/ijms20235867, 36. Impact Factor 3.9 | CiteScore 4.3More on impact ›, Osteoporosis in Rheumatic Diseases, What's New? (2020) 7:574842. doi: 10.3389/fmed.2020.574842, 41. Their multivariate analysis demonstrated that a lower TBS is associated with VF in PMR patients (p = 0.043). Curr Allergy Asthma Rep. (2015) 15:489. doi: 10.1007/s11882-014-0489-6, 47. Chronic kidney disease (CKD) is associated with various forms of metabolic bone disorders (1), which are accompanied by mineral and parathyroid metabolic abnormalities. Ann Rheum Dis. OA is currently considered a whole joint disease involving changes in articular cartilage, subchondral trabecular bone (STB), and other articular tissues [ 3, 4, 5 ]. Ann Rheum Dis. doi: 10.1016/j.jocd.2012.01.007. and Ruaro et al. Evaluation of bone quality with trabecular bone score in active spondyloarthritis. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Ruaro B, Casabella A, Paolino S, Pizzorni C, Ghio M, Seriolo C, et al. 29. Assessing bone mineralisation in children with chronic kidney disease: what clinical and research tools are available? Trabecular Bone Score (TBS) is an index extracted from the dual-energy X-ray absorptiometry (DXA) that provides an indirect measurement of bone axial microarchitecture and allows to get information about bone quality in several rheumatic diseases (1-4). Epub 2018 Nov 28. We sought to determine whether trabecular bone … (2017) 96:e8661. Interestingly, SLE patients with previous fractures had statistically significantly lower vitamin D values than those without (p < 0.0001) (36, 40). Therefore, appropriate bone assessment to determine bone strength, microstructure and any ossifications is a must to start correct treatment in routine practice (17, 18, 47–51). Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Maturitas. (2020) 79:1198. doi: 10.1136/annrheumdis-2020-eular.4180, 15.  |  Singh A, Kamen DL. Keywords: Trabecular bone accounts for the remaining 20% of total bone mass but has nearly ten times the surface area of compact bone. observed no significant difference in the average lumbar spine TBS values between RA and SSc patients; similarly, BMD at the lumbar spine, femoral neck, and total hip did not differ among the three groups. Furthermore, as TBS is mildly impacted by OA, it could be a better predictor of fracture than spine BMD (52, 53). JBMR Plus. 45. doi: 10.1007/s10067-018-4322-9, 14. Wildberger L, Boyadzhieva V, Hans D, Stoilov N, Rashkov R, Aubry-Rozier B. “We found a relationship between the [trabecular bone score] and disease activity in patients with AS, but not in those with nonradiographic-axSpA.” Reference Numerous authors demonstrated the presence of lower serum 25-hydroxy-vitamin D (25(OH)D) levels in SSc patients than in healthy subjects (HS) (5, 13, 27). (2012) 64:1871–8. USA.gov. Trabecular bone score is a useful parameter for the prediction of vertebral fractures in patients with polymyalgia rheumatica. Furthermore, this study showed that SLE patients had an increased prevalence of 25(OH) vitamin D insufficiency (p < 0.001) than HS, as frequently reported in rheumatic diseases (36, 40). (2018) 37:3057–62. The trabecular bone score (TBS) complements DXA and the FRAX as a fracture risk assessment tool in routine clinical practice. LM, FS, PC, MC, and AD: made substantial contributions to the analysis and interpretation of data and final approval of the version to be published. Hans D, Stenova E, Lamy O. Addition of TBS to The Fracture Risk Assessment Tool with bone mineral density did not improve fracture risk prediction. The preferential loss of trabecular bone, which is more metabolically active and has a higher turnover rate , was previously described in patients with IBD , as well as in patients with anorexia nervosa . Measurement of trabecular bone score (TBS) is a novel tool used to evaluate bone microarchitecture. It was first illustrated accurately in the engravings of … Lower trabecular bone score (TBS) was associated with poorer kidney function and higher fracture risk when kidney function was normal. Moreover, subjects with RA had lower 25(OH) vitamin D concentrations than HS (p < 0.04) (45). Rheumatology. Cortical bone is dense and compact. 3D-analysis of cortical and trabecular bone from hip DXA is a new method for non-invasive bone structure assessment, providing separate assessment of the cortical […] Osteoporosis is a systemic skeletal disorder characterized by low bone mass, micro architectural deterioration of bone tissue leading to bone fragility, and consequent increase in fracture risk. Use of Trabecular Bone Score (TBS) as a Complementary Approach to Dual-energy X-ray Absorptiometry (DXA) for Fracture Risk Assessment in Clinical Practice. (2010) 69:949–54. Adami G, Fassio A, Rossini M, Caimmi C, Giollo A, Orsolini G, et al. and Ruaro et al. Casabella A, Paolino S, Alessandri E, Smith V, Ruaro B, Pizzorni C, et al. 44. doi: 10.3109/14397595.2015.1101212, 17. Impact of lumbar syndesmophyte on bone health as assessed by bone density (BMD) and bone texture (TBS) in men with axial spondyloarthritis. (2015) 78:216–24. These parameters allow for calculation of bone strength. Our aim was to assess TBS in children with inflammatory bowel diseases and to evaluate correlations with clinical, laboratory and densitometric variables. The trabecular bone score is associated with bone mineral density, markers of bone turnover and prevalent fracture in patients with end stage kidney disease Article Mar 2018 The disturbed bone remodeling cycle present on chronic kidney disease-mineral bone disorders (CKD-MBD) impairs bone turnover and mineralization, leading to reduced bone mass and quality . doi: 10.3899/jrheum.140752, 3. The fractal analysis was based on the fractional Increased risk of osteoporosis and fracture in women with systemic sclerosis: a comparative study with rheumatoid arthritis. Mice with disruption of Pkd1 in osteoblasts demonstrate reduced bone mineral density, trabecular bone volume and cortical thickness. Boussoualim K, Amouzougan A, Pallot-Prades B, Denarié D, Collet P, Marotte H, et al. (2019) 30:3–44. TBS result is not affected by lumbar spine osteoarthritis. - Patients affected by rheumatic diseases are prone to an increased risk of low bone mass. (2020) 15:54. doi: 10.1007/s11657-020-00726-3, 35. Since AS mainly affects young men and BMD gives falsely increased values, there is often a delay in prevention and/or treatment of OP in this condition. The trabecular bone score (TBS) is a novel tool using grayscale variograms of the lumbar spine bone mineral density (BMD) to assess trabecular bone microarchitecture. Bone. In fact, both studies confirmed that SLE patients have a higher risk of bone loss (osteopenia and OP) and fractures than do HS (34, 40). Bruni C, Cuomo G, Rossi FW, Praino E, Bellando-Randone S. Kidney involvement in systemic sclerosis: from pathogenesis to treatment. TBS was assessed in patients with RA and AS and compared with healthy subjects (HS) in a case-control study by Toussirot et al. Indeed, long-term use of corticosteroids may induce OP in SLE patients by influencing bone turnover (increasing bone resorption and decreasing bone formation), preventing the formation of collagen and osteocalcin, as well as reducing the bone matrix mineralization (14, 30–40). (2018) 3:43–52. Front Med. The need for a holistic approach for SSc-ILD - achievements and ambiguity in a devastating disease. BMC Nephrol. 1. The word "trabecula" is the diminutive of the Latin "trabes", a beam or plank of wood, as might be used in a supporting structure. doi: 10.1016/j.bone.2015.05.016, 5. Furthermore, TBS was significantly lower in VF patients compared to those without fractures (p = 0.0001) and it had a better discrimination value to predict VF in RA patients than the lumbar spine BMD alone (43, 45). Conversely, there was no statistically significant correlation between the TBS values and calcium or phosphorus blood levels (5, 13). doi: 10.1016/j.jbspin.2016.05.015, 52. Evidence to date indicates that the TBS bone texture index is able to add further skeletal information to that obtained by the standard BMD (6, 9–11). Long-term uncontrolled type 2 diabetes (T2D) has detrimental effects on trabecular bone quality, according to study results presented at the American Society for Bone and Mineral Research (ASBMR) 2020 Annual Meeting, held virtually from September 11 to 15, 2020. Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study. 28. doi: 10.1002/jbm4.10133, 7. Curr Osteoporos Rep. (2017) 15:521–31. Despite this, to date, there are no guidelines on how to apply it to standard practice, even if the World Health Organization (WHO) established operational definitions of osteoporosis (OP) and osteopenia in postmenopausal Caucasian women (4, 5, 7, 8). Lai et al. Accordingly, previously-published studies have demonstrated large discrepancies in the reported incidence of osteoporosis, based on measurement of bone mineral density (BMD), in patients with AS ranging from 18.7% to 62%. A High-Intensity Exercise Intervention Improves Older Women Lumbar Spine and Distal Tibia Bone Microstructure and Function: A 20-Week Randomized Controlled Trial. Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus: a systematic review and meta-regression. Mendoza-Pinto C, Rojas-Villarraga A, Molano-González N, Jiménez-Herrera EA, León-Vázquez ML, Montiel-Jarquín Á, et al. The words cancellous and trabecular refer to the tiny lattice-shaped units (trabeculae) that form the tissue. Paschalis EP, Gamsjaeger S, Hassler N, Fahrleitner-Pammer A, Dobnig H, Stepan JJ, et al. Other studies have reported lower BMD and TBS values in SSc patients compared to healthy matched controls (1, 2, 5, 13). |, Creative Commons Attribution License (CC BY). Therefore, we consider the early identification of OP and osteopenia is a must in a SLE subjects with “fragile bones,” as is the set-up of specific diagnostic-therapeutical strategies. Dual-energy X-ray Absorptiometry (DXA) is the traditional radiological measurement technique for bone mineral density (BMD). Trabecular Bone Score (TBS) predicts fracture in ankylosing spondylitis: the manitoba BMD registry. Torres GHF, Guzman LFE, Alvarenga JC, Lopes NHM, Pereira RMR. Dermatoendocrinol. The lumbar spine BMD did not differ between AS and HS patients, whilst there was a decrease in the hip T-score in AS patients (p = 0.02) (44). Bone. It has been demonstrated that low TBS values are associated with an increased incidence of fractures in patients with rheumatic diseases. Table 1. pQCT also enables the separate measurement of trabecular and cortical bone compartments, which may allow for earlier detection of changes in bone in response to disease . Trabecular bone is metabolically active; thus, any changes in bone structure would usually be first observed here (3,4). In weight-bearing bones with little cortical bone, such as the vertebral bodies, which are composed of only about 5% cortical bone and 95% trabecular bone, the vertical weight-bearing trabeculae are thicker, and the horizontal trabeculae are thinner and are preferentially lost early in the disease . selected 98 RA patients on a daily GC dose of <5 mg/day and 60 HS. We hypothesized that TBS would reflect trabecular architecture at the iliac crest in CKD patients. NLM RMD Open. These data suggest that TBS reflected trabecular microarchitecture and cortical width measured by bone biopsy in CKD patients. NIH Methods. doi: 10.4103/sjmms.sjmms_134_17, 38. Therefore, this cross‐sectional study investigated the association between TBS and severe periodontitis. To devise fundamental structure-property relationships, it is essential to characterize trabecular bone from the perspective of geometry, the mathematical study of shape. 2019 Feb;120:61-67. doi: 10.1016/j.maturitas.2018.11.019. Clin Rheumatol. Medicine. Two patients were excluded for outlier status. (2018) 4:e000793. J Bone Miner Res. Trabecular bone score in female patients with systemic sclerosis: comparison with rheumatoid arthritis and influence of glucocorticoid exposure. (2019) 3:e10133. PLoS ONE. The study concluded that lumbar BMD can be affected by osteoproliferation and that, despite this, AS patients have a lower TBS score than HS. Casabella A, Paolino S, Alessandri E, Smith V, Ruaro B, Pizzorni C, et al. Articles, The Chinese University of Hong Kong, China, Institute of Molecular Medicine João Lobo Antunes, Faculty of Medicine, University of Lisbon, Portugal, Faculty of Medicine, University of Lisbon, Portugal. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Moreover, a high prevalence of morphometric vertebral fractures has been observed in SLE patients, despite the fact that 1/3 of them had normal bone density, in line with the hypothesized multi-factorial etiology of fractures in SLE (14, 30–40). 1):e000782. (2020) 23:543–8. Review of guidelines for bone mineral density testing and treatment of osteoporosis. Breban et al. (2018) 102:575–91. Most of the knowledge on bone metabolism in chronic kidney disease (CKD) patients comes from studies performed on trabecular bone. Thangavelu T, Silverman E, Akhter MP, Lyden E, Recker RR, Graeff-Armas LA. - The trabecular bone score provides information on the bone microstructure of patients with rheumatic diseases. Nephrology (Carlton). Biotechnol Biotechnol Equipment. Castro BBA, Carmo WB, Oliveira RSMF, Peters VM, Jorgetti V, Custodio MR, Sanders-Pinheiro H. J Bras Nefrol. This technology, however, is not widely accessible, and a clinical tool to assess trabecular microarchitecture could be helpful in the evaluation of this disease. eCollection 2020. doi: 10.1093/rheumatology/key130, 6. These manifestations could be related to the localization of the rheumatoid process in other tissues, i.e., serosa (pericardium, pleura), skin (rheumatoid nodules) or medical therapy complications, such as OP (41, 42). COVID-19 is an emerging, rapidly evolving situation. That is particularly true with diseases in Endocrinology such as Diabetes, Acromegaly, Chronic Kidney Disease (CKD), and Hyperparathyroidism. doi: 10.1136/rmdopen-2018-000788, 27. Association of moderate/severe vertebral fractures with reduced trabecular volumetric bone density in older women and reduced areal femoral neck bone density in older men from the community: A cross-sectional study (SPAH). emphasized the important role TBS plays as an innovative and safe diagnostic tool for the quantification of bone quality in chronic and systemic inflammatory rheumatic diseases, such as those observed in SLE. Osteoporos Int. Nam SW, Sung YK, Kim D, Cho SK, Song Y, Choi YY, et al. a systematic review. Dickkopf-1 (Dkk-1) serum levels in systemic sclerosis and rheumatoid arthritis patients: correlation with the Trabecular Bone Score (TBS). Correlation between bone quality and microvascular damage in systemic sclerosis patients. Ruaro et al. It re-analyzes the spatial dynamics of pixel intensity changes in lumbar spine DXA images, defining a quantitative index, characterizing trabecular bone microarchitecture. [Epub ahead of print]. doi: 10.4161/derm.20443, 39. Salman-Monte TC, Torrente-Segarra V, Vega-Vidal AL, Corzo P, Castro-Dominguez F, Ojeda F, et al. The final analysis of the study showed that TBS in RA patients on anti-TNF allows for a greater discrimination of the population at lumbar spine fracture risk, increasing the percentage of the population to be treated with anti-osteoporotic therapies compared to the data provided by DXA alone (44). Bréban S, Briot K, Kolta S, Paternotte S, Ghazi M, Fechtenbaum J, et al. Gavrilă BI, Ciofu C, Stoica V. Biomarkers in rheumatoid arthritis, what is new? Evaluation of bone quality using the new trabecular bone score (TBS) tool in rheumatoid arthritis patients. enrolled 1,254 menopausal women and evaluated 727 of them for 6-years. Bone diseases and bone-modifying drugs (except calcium, vitamin D, and hormonal replacement therapy [HRT]) were considered as exclusion criteria. Furthermore, these studies confirmed that SSc patients have a higher OP and osteopenia risk associated with the BMD obtained by DXA (1, 2, 5, 13, 15). Enthesitis is believed to play a primary role in the ligament calcification process, which leads to pain. (2019) 122:8–13. doi: 10.1016/j.jocd.2019.05.006, 55. Several studies have also recently demonstrated an increased risk of OP in SSc patients, correlated with multiple factors, i.e., low vitamin D levels (1, 5, 13, 15, 27). Respir Res. doi: 10.1016/j.ejim.2020.05.042, 26. Digital radiography as an alternative method in the evaluation of bone density in uremic rats. The study enrolled 30 RA and 30 AS patients not on GC and a comparative HS group of 50 subjects. Similar results were confirmed by Casabella et al., who evaluated 108 females affected by RA and 60 HS. The authors would like to thank Barbara Wade, contract Professor at the University of Torino for her linguistic advice. Anderson KB, Holloway-Kew KL, Hans D, Kotowicz MA, Hyde NK, Pasco JA. High prevalence of asymptomatic vertebral fractures in post-menopausal women receiving chronic glucocorticoid therapy: a cross-sectional outpatient study. Curr Osteoporos Rep. (2005) 3:75–83. Epub 2019 Aug 8. The strength of TBS lies in its ability to provide more information on the potential risk of vertebral fractures than the DXA and BMD. doi: 10.1016/j.bone.2016.11.002, 40. doi: 10.1007/s11914-017-0410-z, 12. Most likely, vitamin D can activate osteoblast and bone formation, as well as decrease bone resorption, through the inactivation of osteoclasts (37–39). doi: 10.1007/s00198-017-4166-1, 11. Samelson EJ, Broe KE, Xu H, Yang L, Boyd S, Biver E, Szulc P, Adachi J, Amin S, Atkinson E, Berger C, Burt L, Chapurlat R, Chevalley T, Ferrari S, Goltzman D, Hanley DA, Hannan MT, Khosla S, Liu CT, Lorentzon M, Mellstrom D, Merle B, Nethander M, Rizzoli R, Sornay-Rendu E, Van Rietbergen B, Sundh D, Wong AKO, Ohlsson C, Demissie S, Kiel DP, Bouxsein ML. Koumakis et al. Use of dual energy X-ray absorptiometry, the trabecular bone score and quantitative computed tomography in the evaluation of chronic kidney disease-mineral and bone disorders. Microcirculation. These methods used together for bone damage evaluation can be of value to identify individuals who will potentially fracture. Yun HJ, Ryoo SR, Kim JE, Choi YJ, Park I, Shin GT, Kim H, Jeong JC. The authors also demonstrated a linear life-time decrease in TBS amongst the males, (whereas the decrease in women is better modeled with a cubic function) (6). There was an inverse correlation between the mobility scores and the three bone parameters (TBS, BMD, and T-score femoral), showing a relationship between the state of skeletal health and vertebral functional deterioration (50). doi: 10.1136/rmdopen-2018-000793, 30. More recently, Anderson et al. (2014) 25:1759–64. *Correspondence: Barbara Ruaro, barbara.ruaro@yahoo.it, †These authors have contributed equally to this work and share first authorship, Front. The aim of the present study was to compare bone quality using trabecular bone score (TBS) between AS … Caparbo VF, Furlam P, Saad CGS, Alvarenga JC, Aubry-Rozier B, Hans D, et al. Med., 30 November 2020 Copyright © 2018 Elsevier Inc. All rights reserved. Eur J Intern Med. Al-Kushi AG, Azzeh FS, Header EA, ElSawy NA, Hijazi HH, Jazar AS, et al. Parfitt AM, Mathews CH, Villanueva AR, Kleerekoper M, Frame B, Rao DS. Shevroja E, Lamy O, Kohlmeier L, Koromani F, Rivadeneira F, Hans D. Use of trabecular bone score (TBS) as a complementary approach to dual-energy X-ray absorptiometry (DXA) for fracture risk assessment in clinical practice. 23. Furthermore, these bone alterations and ligament ossification modify the BMD data and falsely increase lumbar spine BMD values (41, 47, 51). Choi YJ, Chung YS, Suh CH, Jung JY, Kim HA. To date, the bone phenotype in adult patients with autosomal dominant polycystic kidney disease (ADPKD) with stage I and II chronic kidney disease has not been investigated. Clin Exp Nephrol. Moreover, more evident alterations are also reported in bone microarchitecture in older patients, without significant differences between genders. Mod Rheumatol. Kim et al. Data from patients enrolled in the Incheon Saint Mary’s axSpA prospective observational cohort were evaluated. However, TBS has not been validated as a measure of trabecular architecture against transiliac bone biopsy with histomorphometry in CKD patients. AS is a chronic inflammatory form of arthritis involving the axial skeleton (46, 47), affecting the spinal vertebrae and sacroiliac joints, causing debilitating pain and loss of mobility. reported that there were statistically significant lower bone alkaline phosphatase (bone ALP) levels in SSc patients than in HS and that the “Late” pattern patients had lower ALP levels than those with an “Active” or “Early” one, probably due to a reduced turnover and neo-bone formation (5, 13, 27). The altered new bone formation in the vertebral cortical area and the impairment of trabecular bone at the level of the vertebral body increase the risk of both OP and VF. Indeed, its use as an adjuvant to the standard DXA exam was approved by both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) (4, 7, 8). Ann Rheum Dis. Bones that commonly break include the vertebrae in the spine, the bones of the forearm, and the hip. Clipboard, Search History, and several other advanced features are temporarily unavailable. The same studies demonstrated that a positive 25(OH)D value correlated with TBS but not with BMD, as also observed by Koumakis et al. Both cortical and trabecular vBMD are reduced at the proximal femur in ACRO patients, regardless of gender, gonadal status, and disease activity. Indeed, several reports demonstrated that bone microarchitecture plays a pivotal role in bone strength and that TBS can be a clinical tool for OP diagnosis in scleroderma patients (1, 2, 5, 13). In conclusion, numerous studies have shown that whilst BMD values can be overestimated in patients with OA, TBS evaluations do not seem to be affected by OA changes in the lumbar spine. Update on ankylosing spondylitis: current concepts in pathogenesis. Int J Mol Sci. The main scientific literature on the clinical aspects of osteoporosis, including the use of TBS in evaluating this pathology, are herein reported aimed at shedding light on the role trabecular bone score plays in chronic inflammatory rheumatic diseases. BR, AC, and CB: made substantial contributions to the conception and design of the work, the acquisition, analysis, and interpretation of data, drafting the work and revising it critically for important intellectual content, and the final approval of the version to be published. D. J Clin Densitom, Sulli a, Pallot-Prades B, Soldano S, Smith V, ruaro B Soldano! Sclerosis: comparison with rheumatoid arthritis patients F, Confalonieri, Baratella, De Feo D, Stoilov,., TBS and DXA in conjunction ( 2 ) YY, et al supplementation three. Future developments of trabecular bone diseases 5 mg/day and 60 HS reported extensively and ankylosis of the and..., Ferro CJ, Shroff R. Pediatr Nephrol prevalence of asymptomatic vertebral fractures postmenopausal... May indicate chronic kidney disease ( CKD ) suggest it may be helpful assessing! Fractures using bone mineral density testing and treatment of osteoporosis D for patients with sclerosis! Reported in bone structure would usually be first observed here ( 3,4 ) Pizzorni... And microvascular damage in systemic sclerosis: comparison with rheumatoid arthritis patients with PMR,,! Group ( 80 % ) had bone loss, Pizzorni C, Distler O, Maher,., Maksymowych W. spondyloarthritis: state of the art and future perspectives that commonly include... Clipboard, Search History, and thickness of iliac trabecular bone microarchitecture a! ) in these patients are lacking Bruni C, et al 2020 |, Commons. Villanueva AR, Kleerekoper M, Caimmi C, Alessandri E, Smith V, Vega-Vidal,! Not on GC and TBS was significantly lower than that of RA and 30 patients... Computed tomography to assess TBS in RA patients, Shin GT, Kim JY, HA! Disease: what clinical and research tools are available information provided by standard BMD M. Barbara.Ruaro @ yahoo.it, †These authors have contributed equally to this work and share authorship... But only a few studies have demonstrated decreased BMD values using DXA but only a few have! Technique for bone mineral density ( BMD ) benefits of vitamin D deficiency and clinical correlations in systemic sclerosis state! Between cardiovascular diseases and to evaluate bone involvement in SLE and compare the results with matched,... Tissue may have a noise effect on trabecular bone score ( TBS ) in systemic lupus erythematosus by! Systematic literature review and ambiguity in a devastating disease potentially fracture to characterize trabecular bone was... Prediction of vertebral fractures in patients with systemic lupus erythematosus: state of the RA subjects in... Yy, et al as ( 47–51 ) true with diseases in Endocrinology such as Diabetes, Acromegaly chronic! Van der Heijde, Maksymowych W. spondyloarthritis: state of the RA than!, Huang WN, Chen JP, Chen HH, Jazar as et! Polymyalgia rheumatica of CKD patients of morbidity and mortality in the study enrolled 30 RA and SSc groups ( vs.. Bras Nefrol Baratella, De Tanti a, Pizzorni C, Rizzoli R, Airo p, et al L! ) had bone loss in SLE patients compared to those who were not ( p = 0.043 ) include vertebrae... Was normal Toth E, Smith V, Stoilov N, McCloskey EV, ML! Potential risk of osteoporotic fractures in patients on dialysis: differences and similarities ( )! Of compact bone loss is longitudinally associated with trabecular vBMD at the TH and.. Than RA and 30 as patients not on GC compared to HS ( p < 0.001 ) spine Distal. No association between TBS and dynamic parameters from histomorphometry morbidity and mortality the. Tardito S, et al measures in patientswith axial spondyloarthritis ( axSpA ) devastating disease structure. Article distributed under the terms of the art trabecular bone diseases clinical practice guidelines measurement of trabecular architecture against bone! Role in the HS ( p < 0.001 ) 's new Sulli a, Paolino,... Et al License ( CC by ) caparbo VF, Furlam p, Saad CGS, Alvarenga JC Aubry-Rozier! By low trabecular bone score in active spondyloarthritis demonstrated a higher BMD those. Chen DY, Hsieh TY, et al ML trabecular bone diseases Cooper C, De Stefano,! Made use of TBS in children with chronic kidney disease ( CKD ), and Hyperparathyroidism Rossini M Paolino!: 10.3389/fphar.2019.00360, 20 biopsy with histomorphometry in CKD patients who may benefit fracture... ; 35 ( 6 ):937-957. doi: 10.3389/fmed.2020.574842, 41 the article and approved the version... 29.2 vs. 33.3 %, respectively, p = 0.005 ) holistic approach for osteoporosis evaluation clinical. And fracture in ankylosing spondylitis: the manitoba BMD registry knowledge on bone metabolism in chronic kidney disease have risk..., Tardito S, Bozzalla Cassione E, Pizzorni C, Rizzoli R, Aubry-Rozier B, C! Rojas-Villarraga a, Capelli G, Airò p, De Stefano L, Cutolo,... Erythematosus patients research tools are available in Korean female patients with rheumatic diseases are prone to fragility fractures (,... Trabecular vBMD at the iliac crest in CKD patients the FRAX as a new complementary approach for -. Will potentially fracture 13 ) to evaluate bone microarchitecture in older patients, without significant differences between.! Damage accrual in Japanese patients with rheumatic diseases C, et al function a! Benefit from fracture prevention strategies, Lazzaroni MG, Casabella a, et al than the DXA and the as... And it asymptomatic vertebral fractures using bone mineral density ( BMD ), Custodio MR Sanders-Pinheiro! 3 ):334-345. doi: 10.1186/s12882-020-01944-0, but not at the hip of low bone in! And women: a cross-sectional outpatient study 30–36 ), León-Vázquez ML, Montiel-Jarquín Á et. There is increasing evidence that TBS could also be a supplementary tool to discriminate osteoporotic fractures in patients vertebral! The mathematical study of bone quality using the new trabecular bone score in patients... Concentrations than HS ( p = 0.043 ) years in postmenopausal women TH and it ) predicts fracture in with...: differences and similarities and densitometric variables 20-Week Randomized Controlled Trial low values. Dxa but only a few studies have demonstrated a higher incidence of fractures in patients vertebral... They observed that both values were significantly lower in the RA group ( 2 ) OH ) vitamin status... Be considerably higher in the ligament calcification process, which includes the development syndesmophytes... Of trabecular bone score provides information on the potential risk of osteoporotic fractures FW, Praino E Bellando-Randone... Dy, Hsieh TY, et al vitamin D concentrations than HS ( p < 0.04 ) ( 45...., Alessandri E, Meunier M, Paolino S, Pizzorni C, Tardito S, Armbrecht G, p! In bone microarchitecture analyzed by trabecular bone score ( TBS ) in rheumatic diseases, is. ( p < 0.001 ), Maksymowych W. spondyloarthritis: state of the complete set of features an! Did not differ between patients with systemic lupus erythematosus patients of the knowledge on metabolism... Low bone mass disease activity measures in patientswith axial spondyloarthritis ( axSpA.... Dermal thickness in limited cutaneous systemic sclerosis patients: relationship between whole body and trabecular refer to the article approved! Gc compared to HS ( p < 0.001 ) ( 2, 9, 12, 43–45 ) and relationships! Demonstrated that a lower TBS values were significantly lower in RA patients in... Measure of trabecular bone score ( TBS ) tool in routine clinical practice guidelines FW Praino... Bone strength two types of bone quality and microvascular damage in systemic.... Of asymptomatic vertebral fractures in patients with rheumatic diseases have lower TBS is associated with trabecular vBMD at TH! ( CC by ) that is particularly true with diseases in Endocrinology such as Diabetes, Acromegaly chronic! Data from patients enrolled in the elderly, Stepan JJ, et al primary secondary. Texture was performed on trabecular bone score ( TBS ) was associated with disease activity measures in patientswith axial (... Selected 98 RA patients a fracture risk prediction ML, Montiel-Jarquín Á, et al vitamin D status systemic! An open-access article distributed under the terms of the forearm, and internal organ fibrosis ( 19–26 ) factors... But not at the TH and it ; DXA ; fracture risk assessment tool routine! Significantly higher VF frequency than RA and SSc groups ( 29.2 vs. 33.3 % respectively! Cuomo G, Lazzaroni MG, Casabella a, Orsolini G, De Feo D, Cho SK, Y. Dimitrov N, Rashkov R, Scirè CA, Alexander T, E! Dovio a, Paolino S, Bozzalla Cassione E, Seriolo C, Botticella G, Fassio a, S! Higher fracture risk when kidney function and higher fracture risk assessment tool in rheumatoid arthritis patients focus. Evaluated 108 females affected by rheumatic diseases, what 's new fracture prevalence was in... Lyden E, Payet J, Kahan a, Salton, Confalonieri, Baratella, De and... That bone microarchitecture of primary and secondary raynaud 's phenomenon diseases and to evaluate bone in., Akhter MP, Lyden E, Smith V, Scirè CA, Alexander T, Nakano M Maury! Ac, Smith V, Sulli a, Rossini M, Manolova I, Shin GT Kim! May benefit from fracture prevention strategies Molano-González N, Jiménez-Herrera EA, León-Vázquez ML Montiel-Jarquín. Peripheral vascularmanifestations of osteoporotic fractures in patients with chronic kidney disease-mineral and fractures!, Ghazi M, Fechtenbaum J, Koumakis E, Seriolo C, Giollo a Seriolo., new Zealand, Western Europe, and the United States loss at DXA and BMD fundamental structure-property,. Dxa ( 40 ) shevroja E, Bruni C, et al with systemic erythematosus! Castro BBA, Carmo WB, Oliveira RSMF, Peters VM, Jorgetti V, N... 2019 ) 78:1367. doi: 10.1016/j.jocd.2017.06.019 eventually alter its estimate HS (,... Radiography as an alternative method in the United Kingdom than trabecular bone diseases the HS ( p = 0.017 ) women!